Berlin Defense of the Ruy Lopez
Gary Kasparov is an acknowledged authority on the Ruy lopez the ideal opening for white.
Other grandmasters like Peter Svidler and Bobby Fischer have had great sucessess with it.
For over 500 years black has looked for a defense. In the 2000 World Championship match in London Vladimir Kramnik found a way to stop the strongest chess player in the world. In this time of computer aided preparation just drawing with black is a small victory.
Four times in the match Gary Kasparov fought to gain an advantage and four times he was turned back.